Mechanism of Action
This enzyme is directly stimulated by vericiguat to increase cyclic GMP levels.
What is soluble guanylate cyclase (sGC)?
Vericiguat was approved by the FDA in this month and year.
What is January 2021?
Vericiguat should be taken this many times per day.
What is once daily?
The two most common side effects of vericiguat are symptomatic hypotension and this___ (blood condition)
What is anemia?
The typical half-life of vericiguat in patients with heart failure is this many hours.
What is 30 hours?
Does Vericiguat bind to the alpha or beta subunit of the sGC enzyme?
What is the beta subunit?
This is the brand name of Vericiguat
What is Verquvo
Vericiguat should be taken with this to optimize bioavailability.
What is food?
Vericiguat is absolutely contraindicated in this patient population due to risk of fetal harm.
Who are pregnant women?
Peak plasma concentration occurs at this time after oral administration.
What is one hour?
This signaling molecule's pathway is impaired in heart failure and is augmented by vericiguat.
What is nitric oxide (NO)?
Vericiguat is indicated for adults with chronic heart failure and an ejection fraction less than this percentage.
What is 45%?
The recommended starting dose of vericiguat is this amount.
What is 2.5mg?
Concomitant use of vericiguat with this drug class (sildenafil & tadalafil) is NOT recommended due to hypotension risk.
What are PDE-5 inhibitors?
Vericiguat has __-affinity to tissues with a volume of distribution around 46L in patients with HFrEF.
What is low affinity?
This second messenger, whose levels are increased by vericiguat, plays a role in regulating vascular tone, cardiac contractility, and cardiac remodeling.
What is cyclic guanosine monophosphate (cGMP)?
Patients must have experienced this event/diagnosis in order to qualify for vericiguat therapy
What is hospitalization for heart failure?
This is the target maintenance dose of vericiguat.
What is 10mg once daily
Vericiguat is contraindicated with concomitant use of other medications in this drug class, such as riociguat.
What are soluble guanylate cyclase (sGC) stimulators?
This percentage of vericiguat is protein-bound in plasma.
Vericiguat works both independently of and synergistically with this molecule to stimulate sGC.
What is nitric oxide (NO)?
These two pharmaceutical companies developed and manufactured vericiguat
Who are Merck and Bayer?
Every ___ week(s), the dose should be doubled to reach the target dose.
What is 2 weeks?
The use of vericiguat should be avoided in patient’s with this diagnosis due to the lack of data from an investigation.
What is severe liver impairment?
The oral bioavailability of vericiguat when taken with food is this percentage.
What is 93%?