Wait, What is Verigene?
What does Verigene test for?
Common gram positive / gram negative bacteria and their resistance genes
Methicillin Resistant
MRSA
What is the most likely reason that no pathogen is detected on Verigene if there is bacteremia?
Likely a result of something that is not tested for on the panel
The Verigene reports out Streptococcus pneumoniae with no resistance genes. What is the best course of action for treatment?
Ceftriaxone
The Verigene reports out Serratia marcescens with no resistance genes. What is the best course of action for treatment?
Cefepime and narrow based on cultures
What type of assay is Verigene?
It is a multiplex DNA assay which allows for prompt characterization of positive blood cultures through bacterial speciation
Verigene results with Enterococcus faecalis that is vanA Positive. What is the resistance of the bug?
Vancomycin Resistant
VRE
Streptococcus mitis can sometimes be reported out as what other pathogen?
Streptococcus pneumoniae
The Verigene reports out Staphylococcus spp. with no mecA resistance genes. What is the best course of action for treatment?
Cefazolin, Nafcillin, or Oxacillin
The Verigene reports out Proteus mirabilis. with no resistance genes. What is the best course of action for treatment?
cefepime or piperacillin/tazobactam and narrow based on cultures
How long does Verigene take compared to traditional cultures?
Average turnaround time at SRHC of 6.2 hours, much quicker than average blood culture result time of 48-72 hours
Verigene results with Escherechia coli that is CTX-M Positive. What is the resistance of the bug?
Extended Spectrum Beta-lactamase
ESBL E. Coli
If Verigene returns without detecting any organism yet the patient is not improving. What is the best course of action?
Continue empiric antibiotics until traditional cultures return
The Verigene reports out Enterococcus faecailis with a negative vanA/vanB gene. What is the best course of action for treatment?
ampicillin
The Verigene reports out Escherechia coli with no resistance genes for a critically ill patient in the ICU. What is the best course of action for treatment?
Cefepime
What type of bacteria will Verigene not test for?
Atypical Bacteria
Verigene results with Enterococcus faecium that is vanB Positive. What is the resistance of the bug?
Vancomycin Resistant
VRE
Klebsiella pneumoniae can sometimes be reported out as what other pathogens?
Enterobacter genus
The Verigene reports out Staphylococcus spp. with a mecA genes. What is the best course of action for treatment?
Vancomycin
The Verigene reports out Pseudomonas aeruginosa with CTX-M resistance genes. What is the best course of action for treatment?
Meropenem
Of the following bacteria, Which will Verigene not test for?
Staphylococcus lugdenesis
Serratia marcescens
Clostroides difficile
Listeria spp.
Clostroides difficile
Verigene results with Pseudomonas aeruginosa that is OXA Positive. What is the resistance of the bug?
Carbapenems (Carbapenemases)
What would be the best course of action for a patient with a penetrating abdominal wound in the ICU that had a positive Verigene result for Escherichia coli with no resistance markers?
Continue Empiric antibiotics until traditional cultures return
The Verigene reports out Enterococcus faecium with a positive vanA resistance gene. What is the best course of action for treatment?
The Verigene reports out Acinetobacter genus with OXA resistance genes. What is the best course of action for treatment?
ID Consult