Metabolism and Viral Infection
Viruses depend on this to carry out metabolism
Swabs used for viral testing should be made of this material to avoid inactivation viruses
What is Dacron of Nylon?
What is more resistant enveloped or non-enveloped and why
non-enveloped
The E6 protein of HPV promotes cancer by degrading this tumor suppressor protein
What is p53?
This DNA virus increases lipid synthesis to build membranes for its replication factories
What is cytomegalovirus?
Some viruses upregulate this metabolic process to produce fatty acids for new membranes
What is lipogenesis
Viral transport media are used to keep viruses stable by maintaining this condition
What is isotonic pH and moisture (preventing drying or pH change)
Viruses consist of:
DNA or RNA and proteins with or without a lipid membrane coat
Retroviruses use this enzyme to copy their RNA into DNA
What is reverse transcriptase
This RNA virus alters glucose metabolism to favor viral RNA synthesis in hepatocytes
What is Hepatitis C Virus?
The shift toward glycolysis during infection, similar to cancer cells, is called this effect.
What is the Warburg effect?
This test amplifies viral nucleic acid for detection
What is PCR (polymerase chain reaction)
What is the primary difference between non-enveloped and enveloped viruses reguarding environmental survival pathogenesis
Non-enveloped viruses have short survival in the environment
What are retroviruses
Influenza virus upregulates glycolysis and this process to produce energy quickly
What is glutaminolysis?
Inhibiting mTOR can suppress replication of several viruses by decreasing this.
What is protein synthesis or anabolic metabolism?
Viral culture is rarely used for these viruses because they are hazardous and require biosafety level 4 labs
What are hemorrhagic fever viruses?
Peplomer/spike is a building block of what type of virus
Envelope
Viral latency contributes to tumor formation because it allows this to persist in host cells
What is viral genome/ viral proteins?
HIV infection increase this metabolic pathway in T cells, supporting viral replication
What is glycolysis and oxidative phosphorylation?
Researchers study virus-metabolism interactions using these small-molecule tracers
What are isotopic or metabolic tracers?
This type of test became widely known during the COVID 19 pandemic for quick home use
What is a rapid antigen test?
What kinds of proteins are in structural and non-structural
Structural: Virion protein
Non-Structural: replication regulatory proteins
Viral oncogenes are often derived from these types of host genes
What are proto-oncogenes
SARS-CoV-2 reprograms host metabolism to enhance synthesis of these biomolecules that form new viral envelopes
What are lipids? (fatty acids or phospholipids)