Isekai
The deadly video game where if you die in the game, you die in real life.
Sword Art Online
Four elements must be mastered by the protagonist in order for him to restore balance to the world.
Avatar: The Last Airbender
To achieve his dream of becoming the Hokage, the most respected ninja in his village, the titular character of this anime will stop at nothing.
Naruto
In this anime, the main protagonist uses a drill key to operate a powerful head with arms.
Gurren Lagann
A 10 year old boy sets out on a journey to befriend all the creatures in the world by capturing them in a ball and sending them to an old man in his hometown.
Pokemon
After dying an extremely embarassing death, this anime follows the struggles of being reincarnated into another world with a useless water goddess.
Konosuba
A professor accidentally mixes a dangerous chemical into his cake recipe, and creates three superheroes.
The Powerpuff Girls
After landing on Earth as little more than an infant, and raised by his adoptive "grandpa," the main character of this anime made many friends along the journey to collect 7 mystical orbs that grant any wish.
Dragon Ball
In the futuristic calendar year "Universal Century" 0079, young civilian mechanic Amuro Ray Pilots this titular machine.
Gundam
A young girl, through the power of plot, becomes a member of a famous wizard guild, and goes on several adventures to save the world.
Fairy Tail
When his favorite vrmmo got shut down for good in this anime, the main character found himself still online after the maintenance, unable to log out, still retaining his position as the Guild Master, and all the NPCs in the guild hall to follow his every command.
Overlord
A boy and his stretchy orange dog go on adventures in a fantasy world
Adventure Time
A half-dog half-demon who is constantly after a jewel of immense power, the Shikon jewel.
Inuyasha
The organization NERV combats monstrous beings called Angels using giant mechas. These giant mechas are piloted by the main cast, including Shinji Ikari, Asuka Sohryu, and Rei Ayanami
Neon Genesis Evangelion
After accidentally opening a deck of monster cards and scattering them across the world, the titular character and the guardian of the cards must work together to collect all the cards and stop them from wreaking havoc on the world.
Cardcaptor Sakura
After a failed summoning, an Elf girl and Cat girl struggle to free themselves from the binding caused by a "magic reflect" ring on their summoned target.
How not to summon a Demon Lord
A bunch of babies sneak out of the child playpen to explore the world on their own.
Rugrats
A young pirate takes a bite of a cursed fruit, and gains the power to stretch his body.
One Piece
Liger Zero is Piloted by several protagonists across the many iterations of this anime.
Zoids
Tokyo Mew Mew
Two siblings who are exceptionally adept at all forms of games find themselves transported to another world where every dispute is settled by gambling your position on a game.
No Game No Life
A yellow sea sponge who gets a part time gig at the local restaurant, and goes about his daily life with his neighbor and best friend, a starfish.
Spongebob Squarepants
A young boy born without powers in a world of superpowered humans gets the opportunity to inherit his idol's superpower, and become the number one super hero.
My Hero Academia
After the tradgedy of "Lost Christmas," this anime follows Shu Oma, and his ability to reach into others' souls and pull them out in the shape of a weapon or tool.
Guilty Crown
From a small, dirt poor town, two young boys who grew up as rivals aim to become the next Wizard King. However, one of them never had any magic power at all.
Black Clover