TP53 is a gene that suppresses this, a mass of abnormal tissue growth; a mutated TP53 is linked with 50% of all cancers
tumors
Many consider cast iron to be the original type of this gym weight that has an attached handle; now "ring" in!
a kettlebell

To hear something with thoughtful attention & making no sound
listen & silent
Antagonistic, like an unfriendly witness in court
hostile
3 undercover women private eyes team up with heavenly helpers of a baseball team
Charlie's Angels in the Outfield
As part of the Treaty of Guadalupe Hidalgo of 1848, this river was set as the primary boundary between the U.S. & Mexico
the Rio Grande
This "re" adjective for a molecule of genetic material means it's been spliced together using DNA from different sources
recombinant

Contrology is the former name of this exercise discipline created by & named for German gymnast Joseph
Pilates
In the buff & a crescent-shaped sand mound
nude & dune
Pronounced one way, it means satisfied; another, it means the stuff a TV network has to show
content
Mrs. Woodhouse is set to have Satan's child, but hires Amy Poehler as a surrogate
Rosemary's Baby Mama
Forming part of the boundary between Serbia & Romania, the Iron Gate Gorge is found on this long river
the Danube

Later suspected in doping, the gene therapy repoxygen was developed to treat this disease by increasing the red blood cell count
anemia

This Chinese martial art has been called "meditation in motion"; balance is important in its series of fluid movements
tai chi
A glowing streak in the sky & an adjective meaning distant
meteor & remote
This term meaning utterly calm precedes "highness" in royal-speak
serene
Meryl Streep is a prime minister growing up as an artistically inclined teenager in Sacramento
The Iron Lady Bird
Often cited as the southernmost point of South America, this rocky headland marks the northern boundary of the Drake Passage
Cape Horn
An abnormal gene on chromosome 4 is the cause of this chorea or disease of the nervous system, described in 1872
Huntington's
At a CrossFit gym, AMRAP stands for this, & the higher the number, the better
as many reps as possible

The main enemy of a novel's hero & a situation of no economic growth
antagonist & stagnation
"The colonel was" this might mean that he no longer felt distressed, or that his command was taken away
relieved
A 19th century sideshow performer is "not an animal" as he escapes to Earth from a dying Krypton
Elephant Man of Steel
After World War I, the Curzon Line was proposed as the boundary between Russia & this newly reconstituted nation
Poland

It's the "T" in the representation G-C-A-T of the 4 nucleic acid building blocks of DNA
thymine

This alphanumeric fitness regimen uses "the advanced science of muscle confusion"
P90X

One bead of fluid from the lacrimal gland & an animal that attacks other animals
teardrop & predator
Doubtful starts with "D"; this 7-letter "D" adjective means the same thing
dubious
George Burns & Walter Matthau remember vaudeville days & navigating being a trans boy in Nebraska
The Sunshine Boys Don't Cry

The world's longest freshwater lake, it forms the boundary between Tanzania & the Democratic Republic of the Congo
Lake Tanganyika