Mechanism of Action
Which cannabinoid receptor is largely responsible for the psychoactive effects of cannabinoids and which is primarily involved in reducing pain and inflammation?
CB1 psychoactive effects by regulating NT release, CB2 reduces pain and inflammation by modulating immune mechanisms.
What is the primary advantage of sublingual administration of cannabis compared to oral ingestion?
Rapid absorption into the bloodstream through the mucous membranes.
What is the most common therapeutic use for cannabis?
Pain management, specifically chronic pain.
What is the term for the tiny, hair-like structures on cannabis plants that produce cannabinoids and terpenes, contributing to the plant's psychoactive and aromatic properties?
Trichomes.
THC acts as an agonist for which receptor?
THC acts as a partial agonist at both CB1 and CB2, mimicking the body’s natural endocannabinoids
What is the primary purpose of using self-emulsifying drug delivery systems (SEDDS) in the administration of cannabinoids?
To improve the oral bioavailability of cannabinoids like cannabidiol (CBD).
Dronabinol and Nabilone are synthetic cannabinoids that are FDA-approved for treating chemotherapy-induced nausea and vomiting. These synthetic cannabinoids act to mimic which component of natural cannabis products?
THC
Which beverage is primarily flavoured using hops (Humulus lupulus), a plant that belongs to the same family as cannabis? BONUS: What is the family name?
Beer! Family = Cannabaceae.
There are two main types of cannabinoid receptors in the body, CB1 and CB2. Where are these receptors primarily found?
CB1 primarily in CNS (frontal cortex, hippocampus, basal ganglia, hypothalamus, cerebellum, spinal cord) and parts of PNS.4 CB2 primarily in cells of the immune system, hematopoietic, and glial cells.4 Both also found in cardiovascular system.4
What is a significant advantage of using cannabis topicals for pain relief?
Localized relief without psychoactive effects.
Hemp plants have been shown effective for phytoremediation. What is phytoremediation?
The process of cleaning polluted sites using plants. Hemp plants do so by absorbing heavy metals and pollutants through its roots.
Where (which animal and which part of animal) was the first endocannabinoid ligand isolated from?
Anandamide aka. Arachidonoylethanolamine (AEA) was isolated from pig brain!