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How can you tell the difference between a Y and X chromosome? Pull down their genes...
Forever young
PHSYCH! Got ya.
What a Pain
Don't put me down for the cardio
100
Describe what Celebrex does and which gene is associated?
Celebrex is an NSAID, or anti-inflammatory that reduces swelling. The associated gene is 2c9. patient could be normal, IM- reduce dose, or PM- 50% dose reduction is recommended.
100
Why are geriatric populations great candidates for PGT testing? (list 3)
1-Pollypharmacy 2-Higher risk/ impact for side effects because of old age 3-Sometime inability to communicate 4-Types of meds commonly prescribed (pain psych cardio, etc)
100
Name the 4 SSRI/ SNRIs reported on, on the front page of the report
Setraline (Zoloft) Escitalopram (Lexapro) Citalopram (Celexa) Venlafaxine (Effexor)
100
What is QTc prolongation?
The QT interval is inversely related to your heart rate, so with a faster heartbeat you QT interval shortens and vice versa with a slower heartbeat. Methadone could prolong the lengths between Q &T, leading to a potentially deadly rhythm.
100
If a patient is a poor metabolizer for 2c19, what might that mean for them while taking Plavix?
Since Plavix is a PRODRUG, it must be metabolized to be converted to the active drug. Patient is at a higher risk for cardiovascular event because it is as if they are not taking the Plavix
200
Describe what Fentanyldoes and which gene is associated?
Fentanyl- pain medication functioning with the genes 3A4/5 and OPRM1 (Normal or reduced expression) which gives more guidance on patient dose.
200
Name the major gene associated with the metabolism of Amphetamine based ADD medication.
What is 2d6
200
Which SSRI reports a genetic indication for QT prolongation?
What is Celexa- Poor metabolizers
200
Whats the PGT pain story?
Boom!
200
What is an alternative medication for Plavix?
Effient, Brillinta, or Ticlid
300
Describe what L-methylfolate does and which gene is associated?
L-methyfolate enables mood stability or improved mood. If a patient is variant for the gene MTHFR, they may be a good candidate for L-methylfolate therapy.
300
When calling on an Assisted Living Facility or Nursing Home, who are the two main targets to speak with?
1- The doctor 2- Administrator 3- Owner
300
Name 3 antipsychotics we report on
Ariproprazole (Abilify) Haloperidol (Haldol) Risperidone (Risperdal)
300
Name 4 opiates that metabolize via 3A4/3A5
Fentanyl, Oxymorphone, Hydromorphone, and Morphine
300
What happens if a patient on Plavix is an UM?
Patient is at higher risk for bleeding
400
Describe what Warfarin does and which gene is associated?
Thins the blood in the extremities, specifically to prevent blood clots or stroke. Dosing recommendations via genes 2c9 and VKORC1 may improve chances of achieving INR strike zone sooner, than through traditional trial and error methods.
400
Please name 4 meds commonly prescribed for ADD (2 amphetamine based and 2 methylphenidate)
Methylphenidate: Concerta, Ritalin, Daytrana®, Metadate CD™, Metadate ER, Methylin®, Methylin ER, Quillivant XR™, Ritalin®, Ritalin LA®, Ritalin SR, Provigil® , Intuniv® Amphetamine: Adderal, Vyvanse, Straterra
400
Why might a physician use Abilify as an “add-on” therapy for a patient taking antidepressants? And based on our new offering, what else might the physician look at to decide if adding on ability if the best course of action?
If they have treatment resistant depression MTHFR- Patient may be a good candidate for DEPLIN add on therapy
400
Dr. Malone says he already does regular EKGs on his patients, and he doesn’t have anyone with an irregular EKG. Explain the benefit of PGT.
PGT is not testing if your patient currently has an irregular EKG, if looks at a particular gene variant indicating that your patient may be at a HIGHER RISK for QTc prolongation. If you did find out that some of your patients had this variant, they may need to be EKG tested more often than the rest of your patient population.
400
What does VKORC1 do?
Clots the blood
500
Codeine functions with which gene? And what does this mean?
2D6- metabolizes codeine to morphine COMT- measures the patients sensitivity to pain (normal, increased activity, or reduced activity) OPRM1- measures whether or not the patient can receive the fullness of the opiate (normal or reduced expresser)
500
What is the brand name for Atomoxetine?
What is Straterra
500
You have one shot, pick one person from your team to do the psych story with MG
Boom!
500
What new information for methadone in addiction will now appear on our reporting?
What is Dosing recommendations
500
What does it mean if a patient’s VKORC1 gene is “greatly sensitive” to Warfarin?
Warfarin thins the blood too much