Winter Break Jeopardy

Bug Coverage

100

(T/F) Vancomycin covers pseudomonas. 

FALSE

200

Draw the flower diagram of PCN G

Coverage (ESPN): Enterococcus faecalis, S. Pneumo, Strep pryogenes, N. meningitidis 

300

Draw the flower diagram for Oritavancin 

All gram (+)

400

Draw the flower diagram for TMP/SMX

Gram (+): MSSA, MRSA, S. pneumo, Strep pyrogenes

Gram (-): ALL except ESBL, CRE, L/M/C, Pseudo 

No BF coverage

500

Which of the following drugs cover CRE? (Select all that apply)

A. Vabomere 

B. Tigecycline 

C. Amikacin 

D. Lefamulin 

E. Xereva 

A, B, E 

Adverse Effects

100

What are AE of Vancomycin? 

Red man's syndrome

Nephrotoxicity 

200

Daptomycin may result in rhabdomyalgia so avoid concomitant ________ therapy. 

statin 

300

List AE of Gentamicin (name at least 2)

Gentamicin is an aminoglycoside so common SE are

-nephrotoxicity 

-ototoxicity 

-neuromuscular blockade

-fetal harm (avoid in pregnancy)

400

List AE of Biaxin (name at least 2) 

Biaxin is the brand name for Clarithromycin which is a macrolide

Common AE of macrolides are:
-QTc prolongation (>500)

-CYP 3A4 inhibitors 

-Hepatotoxicity 

-GI SE

500

List AE of Zyvox (Know at least 2) 

Zyvox is the brand name for Linezolid. Linezolid belongs to the class of oxazolidinones. 

Common AE are:
-Myelosuppresion if >2 weeks of therapy 

-Peripheral and optic neuropathy (irreversible***)

-Lactic acidosis with longer durations (>28 days) 

-Hypoglycemia 

-Cannot be used with 2 weeks of concomitant SSRIs and tyramine containing food due to risk of serotonin syndrome 

MOA

100

MOA of PCN

Inhibit cross-linking for peptidoglycan in the cell wall, leading to autolysis and cell death

200

Which of the following are protein synthesis inhibitors? 

A. Sulfonamides

B. Cephalosporins

C. Polymyxins 

D. Lincosamides

E. Nitroimidazoles 

D. Lincosamides 

300

MOA of vancomycin 

Bind to terminal D-ala-D-ala chains on peptidoglycan in cell wall, preventing further elongation of peptidoglycan chain 

400

Medication classes affected by porin channel degradation: 

A. Glycopeptides

B. Fluoroquinolones

C. Lincosamides 

D. Beta-lactams 

E. Oxazolidinones 

B. Fluoroquinolones

500

List STATIC antibiotics (name at least 3): 

-Macrolides 

-Tetracyclines

-Glycyclines 

-Oxazolidinones 

Clinical Pearls/Random

100

_______ are the drugs of choice for ESBL infection. 

Carbapenems 

200

Fidaxomicin is useful in ____________ infections ONLY. Cannot be used in against other infections. 

C. diff

300

Patients taking Bacrim have a high risk of anemia so this antibiotic should not be used if patient has ________ deficiency. 

G6PD

400

List AE of Bactrim (list at least 3)

-Hypersensitivity reaction 

-Bone marrow suppression and thrombocytopenia

-Hyperkalemia

-Photosensitivity 

-INR increase

-Transient increase of SCr

500

Bezlotoxumab should be avoided in patients with ____________. 

heart failure 

Movies

100

In SSI lecture, Rachel said her favorite movie is...

John Wick 

200

What does hakuna matata mean? 

No worries 

300

Inigo Montoya is a character from which 1987 iconic Rob Reiner film?

The Princess Bride

400

Who was the first character to speak in the first Star Wars movie?

C3PO

500

What are the names of the infinity stones? 

The Space Stone, the Reality Stone, the Power Stone, the Mind Stone, the Time Stone, and the Soul Stone