Young Boys in Sticky Situations

Shabooey

100

Whats the main species responsible for cellular and dna damage in aging?

ROS/Free radicals

200

Irreversible arrest of cell growth/division

Senescense

300

Which core compensatory mechanism is lost/used to maintain baseline in aged organisms?

Adaptive Homeostasis

400

Vessels stiffen with age due to loss of what protein

Elastin

500

Increase in what protein in blood vessel walls leads to a decrease in the ability to increase GFR?

Collagen

Kavitha

100

What color is Prof Joanna Bridger's hair?

purple

200

Irreversible arrest of cell growth/division from too many divisions.

Replicative senescence

300

Senescent cells secreting negative compounds and causing cells near them to become senescent.

Senescent Associated Secretory Phenotype (SASP)

400

Nuclear envelope protein deficient in senescent cells

Lamin-B1

500

What is the tissue level cause of a 70yo being more likely to die of heatsroke than a 20yo in the same weather conditions?

Decreased vascular network with age -> decrease thermoregulation.

Tamil Nadu

100

Drugs that kill senescent cells are called

Senolytics

200

Irreversible arrest of cell growth/division in order to inhibit tumourgenesis.

Oncogene Induced Senescense

300

Senescent Astrocytes lead to what disease?

Parkinsons

400

Senescent Foam Cells contribute to what complication of atherosclerosis?

Atheroma rupture & Embolism

500

Increased sympathetic activity in the elderly contributes to what chronic condition?

Hypertension

Testicular torsion

100

Hallmark of ageing

Progressive reliance on homeostatic reserves

200

Irreversible arrest of cell growth/division due to external noxious stimuli

Stress Induced Premature Senescence (SIPS)

300

What common rock contributes to cellular damage by ionizing radiation?

Granite

400

NF-KB pathway inhibited by what drug?

Metformin

500

The mean age of onset for Pernicious Anemia is 60, what explains this?

Decreased absorption of Vitamin B12 with age.

Jungle Diff

100

Percentage of UK population over 65 in 2019

19%

200

Term for progressive loss of the tips of chromosomes over many divisions

Telomere Attrition

300

Senescent adipocytes lead to what condition?

Insulin resistance/T2DM

400

Tumour supressor pathways maintaining cell senescence

p53/p21, p16^lnk4a/retinoblastoma protein (pRb)

500

Increased levels of what hormone contribute to osteoporosis in post menopausal women

FSH