Drug Target
A protein that speeds up the rate of a chemical reaction (catalyst)
Enzyme
The term describing the drug concentration associated with a specific response
Potency
The range of drug doses causing safe, effective therapy
Therapeutic window
A protein the helps move molecules through cell membranes, sometimes requiring ATP
Transporter
The term referring to the level of response of a drug
Efficacy
Comparing drug concentration-receptor binding curves for a single drug and different receptors can tell this
Drug selectivity for receptor binding
A protein on the cell surface that transduces a signal from outside the cell to the inside of the cell
Membrane receptor
A drug that produces <100% response
Partial agonist
The effective dose of a drug that produces a 50% response is called this
ED50
A protein that permits charged molecules to move through a cell membrane
Ion channel
A drug that produces maximal response (100%)
Full agonist
This type of drug will shift the dose-response curve of an endogenous agonist to the right
Competitive antagonist
A protein inside a cell that transduces a signal to cause changes in gene expression
Nuclear receptor
A drug that binds a receptor but fails to stimulate a second messenger
Antagonist
Comparison of the drug dose causing a therapeutic benefit to that dose causing a toxic effect is often called this
Therapeutic index