lets get it
Which type of lipase mobilizes fatty acids from adipose tissue
hormone sensitive lipase
Phosphatidic acid is an example of ...
Plasmologens and PAF are examples of ..
G3P; DHAP
What are the 2 enzyme cofactors of apolipoproteins
C2 lipoprotein lipase, A1 for LCAT
What binds a receptor and undergoes receptor mediated endocytosis-
chylomicron, chylomicron remnant, LDL, VLDL, IDL
chylomicron remnant, LDL, IDL
What is cholesterol synthesized from
acetyl coa
Starting molecule of trialglycerol and phosphoglycerol biosynthesis
glycerol-3-phosphate (monoacylglycerol in intestinal epithelial cells)
DHAP is derived from
pyruvate
Apo B100 and Apo E work for what receptor
LDL
What is an example of hyperlipidemia
diabetes, lifestyle, diet
What enzyme catalyzes the committed rate and rate limiting step in cholesterol biosynthesis
HMG coA reductase
During the fed state, glucose is used to generate ______ which is reduced to G3P.
BONUS: what intermediate in this is common to both triaylglycerols and phosphoglycerols
DHAP; phosphatidic acid is the common intermediate
A2: pancreatic fluid and snake venoom
C: toxin secreted by bacteria
D: mammalian signal transduction
Apo B 48 mediates what secretion
secretion of chylomicrons from GI to lymph nodes(delivered via thoracic duct to systemic circulation)
Which type of primary hyperlipidemia-
causes pancreatitis, buildup of chylomicrons + triglycerides+ VLDL
type 5
Name the 5 steps of cholesterol synthesis
1. synthesis of mevalonate from acetyl coa
2. form isoprene's units from mevalonate
3. condense 6 isopreni units to form squalene
4. cyclicization of squalene -> lanosterol
5. formation of cholesterol from lanosterol
What is the branching point for triaclglycerol and phosphoglycerol biosynthesis?
1,2-diacylglycerol to CDP-diacylglycerol
Sphingosine is made from this amino acid and fatty acid
BONUS: what is the backbone and base
serine and palmitate
BONUS: sphingosine backbone, ceramide base
What enhances lipoprotein lipase activity
insulin
What is the difference between type 2A and B primary hyperlipidemias
2A; buildup LDL and cholesterol
2B; buildup of LDL, cholesterol, VLDL
both cause achilles tendon, xanthoma, corneal arches
How does insulin activate cholesterol synthesis? What about the affect of glucagon and intracellular sterols?
insulin activates by activating phosphatase
glucagon and sterols activate Amp activated protein kinase
PAF is an example of this lipid
glycerol ether phospholipids
In MS, what is the affect on phospholipids, white matter, gray matter, and CSF composition
Loss of both phospholipids and sphingolipids from white matter. Lipid composition of white matter resembles gray matter. CSF has elevated phospholipid levels
What method are chylomicron remnants taken up by the liver
receptor mediated endocytosis
What is abetalipoproteinemia? What is deficiency?
BONUS 500: name 1 of the disorders
No VLDL, LDL, or chylomicrons; deficient of Apo B 48 and B100
acanthocytes present
BONUS: retinitis pigments and spinocerebellar degeneration
Explain enterohepatic circulation <3 sorry I asked if you hated yourself <3