Acids with Attitude
Inhibition Inquiries
The Encyclopedia of Enzymes
High on Hemoglobin
What about Wild Cards?
100
The amino acid whose side chain only contains a single methyl group
What is Alanine?
100
The type of inhibition that decreases Vmax, but leaves Km unaffected
What is noncompetitive Inhibition?
100
A tightly bound group to an enzyme that is not made of amino acids, but still critical to the function of that enzyme.
What is a prosthetic group?
100
Cooperativity explains this phenomenon in hemoglobin.
What is hemoglobin's ability to bind oxygen easier as more oxygen bind?
100
The two structures associated with secondary protein structure
What are alpha helices and beta pleated sheets?
200
The amino acid that looks like this:
What is glutamine?
200
The enzyme will experience these changes to Km and Vmax when bound to an uncompetitive inhibitor
What is a decreased Km and Vmax?
200
The enzyme that utilizes a catalytic triad
What is chymotrypsin?
200
This specialized molecule can stabilize the "T" state of hemoglobin
What is 2-3-BPG?
200
A pathogen that solely consists of amino acids
What is a prion?
300
The amino acid responsible for disulfide bonds
What is Cysteine?
300
The site in which a noncompetitive inhibitor will bind to
What is the allosteric site?
300
The maximum speed at which a given enzyme will catalyze a reaction.
What is Vmax?
300
Hemoglobin can bind and release oxygen much easier in this state.
What is the "R" state?
300
The change in entropy as a protein folds.
What is -deltaS?
400
The group of amino acids that generally have a protonated side chain at physiological pH
What are basic amino acids?
400
The condition in which a competitive inhibitor will bind
What is when substrate is not bound to the enzyme?
400
The role of histidine in the chymotrypsin mechanism. (think nucleophile/electrophile, acid/base)
What is a base and acid?
400
The condition that causes sickle-cell hemoglobin to polymerize.
What is the exposing of a hydrophobic patch in sickle cell hemoglobin during the "T" state?
400
The type of secondary structure represented by shading in the top left region of a Ramachandran plot
What are alpha helices?
500
The one-letter code equivalents to this peptide chain:
What is RVY?
500
Uncompetitive inhibition will cause Km to decrease, which by itself will result in this effect on enzyme velocity.
What is increased enzyme velocity?
500
The definition of Km conceptually.
What is the substrate concentration [S] at 1/2 of Vmax?
500
This structure can freely move once an oxygen binds to a hemoglobin monomer, affecting R and T state equilibrium.
What is the alpha helix attached to the heme group?
500
This condition allows for a spontaneous reaction when change in S is negative.
What is when change in enthalpy is negative?