Pregnancy or not
EPS
CL
CYPs
Black box warnings
100

Which SSRI to avoid in pregnancy?

Paroxetine

100

Which dopamine pathway controls the development of EPS?

Nigrostriatal pathway

100

CNS diseases such as TBI or seizures INCREASE or DECREASE threshold for CNS side effects

Decrease

100

What 3 benzodiazepines are not metabolized by CYP3A4?

LOT (lorazepam, oxazepam, tamazepam)

100

What two meds have Stevens-Johnson syndrome as a warning

Carbamazepine

Lamotrigine

200

Lithium exposure in the 1st trimester increases the risk of:

Ebstein's anomaly/cardiac malformations

200

What two EPS syndromes are more likely to occur in elderly females?

Drug-induced parkinsonism and tardive dyskinesia

200

Antidepressants that are the lowest risk for GI bleeding (hint: 2 of them)

Mirtazapine and Bupropion

200

Name 2 antidepressants that inhibit CYP2D6?

Paroextine, fluoxetine, bupropion, duloxetine

200

Elderly patients with dementia have increased risk of death with which class of meds?

Antipsychotics

300

SSRI use in pregnancy increase the risk of what in the newborn?

Persistent Pulmonary Hypertension (from 2 in 1000 to 3 in 1000)

300

What two neurotransmitters are responsible for EPS?

DA and Ach

300

What antidepressant is preferred in short-gut syndrome? 

escitalopram

300

What two antipsychotics are primarily metabolized by CYP 1A2?

Clozapine and Olanzapine 

300

Name 3 warnings with clozapine

Severe neutropenia, myocarditis, orthostatic hypotension, seizures

400

Which mood stabilizer decreases contraceptive efficacy?

Lamotrigine

400

Which EPS is the most deadly? and why?

Acute dystonia leading to laryngospasm

400

Name 2 drugs that can be removed by dialysis?

Lithium, Gabapentin, Pregabalin, Valproate, topiramate, levetiracetam

400

Fluvoxamine is a potent inhibitor of: (name 1)

1A2 and 2C19

400

Name one drug with black box warning for hepatotoxicity? 

Valproate and Naltrexone

500

What mood stabilizer/antipsychotic is the safest in breast feeding?

Quetiapine or Olanzapine

500

Which rating scale assesses for all EPS

Extrapyramidal Rating Scale (ESRS)

500

What antidepressant can you not give in liver disease?

Duloxetine

500

Patient is on tamoxifen and codeine, what enzyme metabolizes these drugs? 

CYP2D6

500

Suicidality in adolescents and young adults, of the 3 antipsychotics that are listed, name 2: 

Abilify, Brexipiprazole, quetiapine

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