Endocrinology and Metabolism (EM)
Enzyme deficiency characterized by virilization, hypotension, hyperkalemia, and cortisol deficiency
21-hydroxylase deficiency
Hematologic malignancy associated with translocation of chromosomes 15 and 17
Acute promyelocytic leukemia
This Canadian physician is often called the "Father of Medicine" and is refered to as "the consummate internal medicine physician" by ACP
Dr. William Osler
These three beta blockers have mortality evidence in heart failure with reduced ejection fraction (note, salt must be specified for one of these medications)
Bisoprolol, carvedilol and metoprolol succinate
The Canadian Cardiovascular Society recently updated its classification of heart failure to include heart failure with reduced ejection fraction and this designation of heart failure
Heart failure with nonreduced ejection fraction (not "preserved")
Autoimmune skin condition associated with autoimmune adrenalitis
Vitiligo
The study of heritable alterations in gene expression that occur outside of the DNA sequence
Epigenetics
These Canadian physicians are credited for discovering insulin.
Banting and Best
Sir Frederick Banting, MD, and Charles Best, MD
Selective serotonin reuptake inhibitors (SSRIs) are a potential culprit of this electrolyte abnormality
Hyponatremia
This is a potentially life-threatening adverse effect of SGLT2 inhibitor medications
(Euglycemic) diabetic ketoacidosis
The most common secretory pituitary tumour
Prolactinoma
Disease caused by beta-globin mutation leading to vaso-occlusion
Sickle cell disease
The first female physician to practice in Canada
Dr. Emily Stowe
Would also accept Dr. Jennie Kidd Trout (first licensed in Canada)
The CANVAS Program study showed a two-fold increased risk of lower limb amputations vs placebo for this SGLT2 inhibitor
Canagliflozin
These are the three (3) irregularly irregular rhythms that can be seen on ECG
Atrial fibrillation, wandering atrial pacemaker (WAP), multifocal atrial tachycarida (MAT)
Prednisone threshold dose of any duration that does not require perioperative testing or replacement to prevent adrenal crisis
Less than or equal to 5 mg/day
Ability of a mutation in a single gene to produce more than 1 phenotypic effect
Pleiotropy
This Canadian politician is often credited as the "Father of Medicare" and was voted the Greatest Canadian in a CBC poll in 2004
Thomas "Tommy" Douglas
This thiazolidinedione medication received a black-box warning in the US for risk of heart failure and myocardial ischemia
Rosiglitzaone (Avandia)
Hypokalemia from hypomagnesemia is thought to be caused by a lack of inhibition of this channel on the apical surface of the distal nephron
ROMK (Renal outer medullary potassium channel)
Most prevalent type of clinically nonfunctioning pituitary macroadenoma
Gonadotroph adenomas
First patient with sickle cell disease treated ex vivo with this approach
CRISPR Cas 9
This neurologist was the first Canadian woman astronaut
Dr. Roberta Bondar?
Sacubitril inhibits neprolysin, which prevents the breakdown of what beneficial peptide in heart failure
Atrial natiruretic peptide
Chronic ingestion of this sweet treat can lead to apparent mineralocorticoid excess with hypertention and potentially life-treatening hypokalemia
Licorice/liquorice (glycyrrhetinic acid)