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Relationship between neurotransmitters GABA (inhibitory) and Glutamate (excitatory) during alcohol withdrawal.
What is that GABA has been increased while drinking alcohol (causing calming/depressive effect on CNS), so glutamate increases to compensate. Then when alcohol is out of the system (ie. withdrawal), glutamate remains high, with no GABA to compensate as it was depleted/"burnt out". High glutamate (excitatory) leads to tremors, anxiety, restlessness, etc.