The Disease
This is the projected number of people living with Alzheimer's by the year 2050.
What is 139 Million
These enzymes, specifically β and 𝛾, are responsible for cutting proteins into toxic fragments.
Secretases
This type of AI model is a "visual tool" used for spotting physical brain atrophy in images
CNNs
These traditional medical tests for Alzheimer's are often considered too expensive for early detection.
PET scans or lumbar punctures
Alzheimer's is described as this type of complex, multifactorial disorder
Neurodegenerative
These toxic fragments, Aβ40-42, eventually clump together to form these outside of neurons.
Plaques
This type of model views the brain as a web of "nodes and edges" to map biological pathways
GNNs
New tools from this University can predict the progression of Alzheimer's with 80% accuracy.
University of Cambridge
At the cellular level, this process occurs inside the cell when tau tangles form.
Hyperphosphorylation
Triggered by Aβ40-42, GSK3 and CDK5 create these, leading to cell death
Tau Tangles
AI can predict if a drug can pass through this protective wall, which blocks 98% of drugs
Blood-Brain Barrier (BBB)
This is the current estimated cost to develop a single drug for clinical trials.
$2.6 Billion
During this clinical stage, the patient appears healthy but plaques are already forming.
Preclinical
This is the term for "programmed cell death" that results from the signaling pathway failure
Apoptosis
This specific AI model targets mitochondrial health and glucose metabolism to power up dying neurons
DeepDrug
AI categorizes patients into these three progression groups: Stable, Slowly Progressive, or this
Rapidly Progressive
This term refers to the shrinkage and decrease in size of the brain during the Dementia stage
Atrophy
This is the estimated annual worldwide cost of "Informal Care" for Alzheimer's patients
$520 Billion
These two specific drugs are mentioned as a synergistic combination to reduce inflammation
Empagliflozin and Baricitinib.
This is the failure rate percentage for drugs currently in clinical trials.
90%