Microbiology
Gram stain and metabolism
What is Gram-positive anaerobic bacillus?
Most common symptom
What is watery diarrhea (>3 loose stools in 24h)?
Initial diagnostic test
What is GDH antigen and toxin A/B in stool?
First line treatment for nonsevere CDI based on 2021 IDSA guidelines
What is fidaxomicin?
Risk factors for recurrent CDI
What is age > 65, severe underlying medical disorder, serum creatinine ≥ 1.2 mg/dL, lack of antibody-mediated immune response to toxin B?
Three main clinical presentations
GDH antigen positive and toxin A/B negative: next step
What is toxin B gene PCR (NAAT) if meeting criteria for disease?
First line treatment for recurrent CDI (first recurrence)
What is fidaxomicin?
Three antibiotics (or classes) often associated with CDI
What is fluoroquinolones, clindamycin, cephalosporins (2nd generation and above), carbapenems, penicillin?
Mechanism of infection
What is spore ingestion?
Definition of severe disease
What is WBC >15000 cells/µL or serum creatinine >1.5 mg/dL?
Two tests that when positive may lead to overdiagnosis of colonization
What is GDH and toxin B gene PCR (NAAT)?
First line treatment for severe CDI
Color of container lid for appropriate wipes to use for CDI prevention (sporicidal)
What is orange?
Bacterial forms
What is spore and vegetative?
Definition of fulminant colitis
What is hypovolemic shock, ileus or megacolon/bowel perforation?
Two less common laboratory diagnostic tests for CDI
What is selective anaerobic culture and cell culture cytotoxicity assay?
First line treatment for fulminant colitis (dose and frequency)
What is oral vancomycin 500 mg q6h and IV metronidazole 500 mg q8h for
Target of Bezlotoxumab
What is toxin B?
Hypervirulent strain
What is NAP1/B1/027?
Definition of recurrent disease
What is reappearance of symptoms within 2-8 weeks after treatment has been stopped?
Unhelpful stool test for CDI
What is fecal leukocyte testing?
Most appropriate timing of FMT
What is after third recurrence?
Name of first FDA-approved fecal microbiota product to prevent recurrent CDI
What is Rebyota?