Types of Dementia
This dementia presents with gradual onset of memory impairment, followed by language and visuospatial deficits.
Alzheimer's dementia
True or false: Dementia is a normal part of againg?
False
Initial laboratory workup for cognitive decline should routinely include TSH and which vitamin deficiency?
Vitamin B12
What is the first line management for Alzheimer dementia?
Non-pharmacological interventions (cognitive stimulation, exercise, massage, music..etc)
This dementia is characterized by a stepwise decline in cognition, often following strokes or transient ischemic attacks.
Vascular dementia
This neurocognitive disorder is characterized by extracellular β-amyloid plaques and intracellular tau neurofibrillary tangles?
Alzheimer’s disease
The sensitivity of this cognitive assessment for detecting mild cognitive impairment is ~ 90%.
Montreal Cognitive Assessment (MoCA)
Which neurotransmitter is targeted by the medication Donepezil?
Acetylcholine
Fluctuating cognition, visual hallucinations, and REM sleep behavior disoreder are core features of which type of dementia.
Lewy Body dementia
This type of dementia is associated with cerebrovascular insults (eg. lacunar infarcts)
Vascular dementia
Anterior temporal lobe atrophy on MRI is most characteristic of this type of dementia.
Frontotemporal dementia
This medication is an NMDA receptor antagonist used in moderate to severe Alzheimer’s dementia.
Memantine
This type of dementia presents with early personality and behavioral changes, language impairment with relative preservation of memory.
Frontotemporal dementia
This type of dementia is characterized by intracellular α-synuclein aggregates
Lewy body dementia
Medial temporal lobe atrophy on MRI is most characteristic of this type of dementia.
Alzheimer's dementia
This FDA approved disease modifying antibody for early AD targets soluble aggregates of beta-amyloid.
Lecanemab
This dementia presents with motor symptoms > 1 year before cognitive decline.
Parkinson’s disease dementia
This type of dementia involves abnormal TDP-43 or tau protein deposition
Frontotemporal dementia
This CSF biomarker pattern (↓ Amyloid-beta 42 , ↑ tau) supports the diagnosis of which type of dementia?
Alzheimer's dementia
This FDA approved disease modifying antibody for early AD and targets deposited amyloid plaques.
Donanemab