Alzheimer's
Alzheimer's is the neurodegeneration of what
What is Brain Cells
MAPT splices into what number of isoforms
What is 6 Isoforms: 0N3R, 0N4R, 1N3R, 1N4R, 2N3R and 2N4R
What is fibroblasts
FTD patients have a what mutation
What is 10 + 16 site mutation
Alzheimer's affects cognition and what
What is behavior
These 2 isoforms are present in equal amounts
What is 3R and 4R isoforms
Fibroblasts were transduced using what viral
What is cMyc, Oct4, Sox2, and Klf4
10 + 16 mutation destabilizes what
What is stem loop
Alzheimer's currently has no what
What is Treatment/Cure
Tau is healthy in the adult brain until it begins to form what
What is Tau Plaques
What is neurons
exon 10 increase can override what
What is regulation of tau splicing
Alzheimer's is incurable due to the lack of understanding of what
What is mechanisms
Tau Plaques degrade what
What is healthy neurons
What is 0N3R tau
after 100 days, iPSCs with 10+ 16 mutation showed what
Alzheimer's will affect what number of people by 2050
What is 100 million
Most tau splicing mutations occur at what
iPSCs have the potential to model what
After 365 days, 10 + 16 iPSCs expressed higher forms of what than control cells
What is 4R isoforms