SARMS
What is 1 medical disease treated with SARMS?
muscle wasting, cancer, muscle dystrophy, osteoporosis
Erythropoietin (EPO) is released by what endocrine gland?
Kidneys
What hormones typically bind to these receptors?
Epi/Norepinephrine
What would aromatase inhibitors cause?
Decreased conversion of testosterone to estrogen
Where are athletes purchasing SARMS?
Blackmarket, Animal drugs, un-healthy supplements
What is a typical hematocrit range for males?
40 - 50%
What are 3 side effects of beta 2 agonists?
Many....
•Tachycardia, Cardiac arrythmia, High blood pressure, Anxiety/shakiness, Headache, Sweating, Cramps
What modulator had a significant spike in use when WADA started testing for it?
Meldonium
What is the key (specific) benefit of SARMS in bone compared to other therapies?
SARMS may help deposit bone (osteoblasts). All other therapies just decrease reabsorption (osteoclasts)
What is growth hormone composed of?
Protein
How long do the effects of typical short-acting beta-2 agonist medication last?
< 5 hours
Describe 2 of the major classes of modulators
Describe 1 potential theory behind why SARMS cause tissue specific effects.
How do Cobalt and Xenon increase athlete performance?
Stimulating Hypoxia inducible factor (HIF) to increase hematocrit through EPO production
Explain how beta-2 agonists metabolic effect influence exercise performance?
Lipolysis of adipose tissue causes greater reliance on lipids. + body composition long term and glycogen sparing during exercise.
Explain the effect insulin has in 3 types of tissue
Resting muscle: increase AA uptake, protein synthesis, decreased breakdown, glycogen synthesis
Adipose: Increase FFA synthesis/decreased breakdown
Liver: Increase glycogen synthesis
More....