Experiments
What did the baby hamster kidney experiment show for mutants I, II, and IV?
What does WES stand for?
Whole Exome Sequencing.
What does ADCY3 do to ATP?
ADCY3 catalyzes ATP into cAMP and pyrophosphate.
Which type of mutation inheritance is responsible for affecting the functionality of ADCY3?
Two copies of the recessive allele
What is the function of forskolin?
Stimulates adenylate cyclases.
Why were only two mutant proteins modeled?
Structural data for important domains was only available for ADCY3 Mut-I and Mut-II
What symptoms did mice with their ADCY3 gene knocked out show?
Was there stabilization or destabilization in the mutADCY3 catalytic domains during the stimulations?
destabilization