Blood cells
At this stage of granulocyte development, secondary granules develop and cell fate is decided
This form of immunity involves recieving immune cells and proteins from another person
Passive immunity
This membrane-bound receptor is a monomer that recognizes flagellin proteins
TLR-5
Self reactive T-cells that evade destruction undergo this process resulting in suppression or death
Peripheral tolerance
This protein binds tightly to CD28 resulting in deactivation of T-cell response
CTLA-4
Immature red blood cells cluster around this cell for support and growth signaling
Macrophage
The production of IL-1 requires which two internal signals
NF-kappaB and inflammasome
This cytokine is secreted in virally infected mucosa and induces an antiviral state in nearby cells
Interferon-3
This cancer treatment uses modified antigen receptors that contain all intracellular components required for full activation
CAR-T cell therapy
This lymphocyte subtype is specialized in killing intracellular pathogens
Th1
This APC has long projections and possesses B7 allowing it to activate naive T-cells
Dendritic Cell
Integrins on neutrophils strongly bind this molecule to exit the blood stream
ICAM-1
This cytosolic protein allows self antigens into the ER to bind Class 1
Transporter associated with Antigen Processing
TAP
After TLR activation, NEMO is degraded releasing IKKb to phosphorlyate this protein releasing NF-kappaB
I-kappa-B
These antibodies target the variable region of another antibody
Idiotype
This lymphoid organ is a hemicapsule and deep crypts to increase surface area
Tonsils
The presence of viral DNA activates the STING complex stimulates which intracellular signals
NF-kappaB
IRFs
This leukocyte kills cells it contacts unless they present a functioning Class 1
Natural killer cells
Sphingosine-1-phosphate receptor 1
S1PR1
In the germinal light zone, this process ensures only cells with high binding affinity survive
Immature T-cells in this region face destruction following excessive binding to self antigens
Activated macrophages use this enzyme to produce ROS inside phagosomes
Phagocyte oxidase
Cell surface CD59 blocks this complement component permitting cell survival
MAC
C9
These adhesion proteins are expressed on endothelial cells to home effector T-cells to the site of infection.
P- and E-selectins
Class switching to IgA requires CD40 binding and this cytokine
TGF-b