Cardiovascular System
Which of the following is contra-indicated in patient with Hypertension and Diabetes mellitus?
a) Lisinopril
b) Amlodipine
c) Propranolol
d) Telmisartan
Propranolol
Which of the following anti-epileptic drugs acts by blocking voltage-gated sodium channels in their inactivated state?
A) Vigabatrin
B) Phenytoin
C) Ethosuximide
D) Diazepam
Phenytoin
Which of the following agents can result in severe hypoglycemia?
a) Dapagliflozin
b) Pioglitazone
c) Glimepiride
d) Semaglutide
Glimepiride
A strict vegetarian presents with megaloblastic anaemia, glossitis and peripheral neuropathy. Which therapy is most appropriate?
a) Oral folic acid
b) IM hydroxycobalamine
c) Oral hydroxycobalamine
d) Iron therapy
IM hydroxycobalamine
When de-challenge and re-challenge for a drug is not done, the WHO-UMC causality assessment will be:
a) Certain
b) Probable
c) Possible
d) Unlikely
Possible
Class III anti-arrhythmic agents primarily exert their cardiac actions by blocking which of the following currents?
A) Inward Na current
B) Outward K current
C) L-type Ca current
D) Pacemaker current
Outward K current
Which intravenous anesthetic agent is contraindicated in patients with acute intermittent porphyria?
A) Etomidate
b) Thiopentone
c) Propofol
d) Ketamine
Thiopentone
Corticosteroid therapy should be tapered gradually mainly to prevent?
A) Hypernatremia
B) Hypoglycaemia
C) Hypotension
D) Osteoporosis
Hypotension
Folinic acid is specifically indicated in?
a) methotrexate toxicity
b) neural tube defect prophylaxis
c) sickle cell anemia
d) cyanide poisoning
methotrexate toxicity
Which of the following fixed dose combinations show an additive action?
a) Levodopa + Carbidopa
b) Beta-lactam + Clavulanic acid
c) Sulfonamide + Trimethoprim
d) Paracetamol + Aspirin
Paracetamol + Aspirin
Which of the following electrolyte imbalances is most commonly associated with digitalis toxicity?
A) Hyperkalemia
B) Hypokalemia
C) Hypernatremia
D) Hyponatremia
Hypokalemia
Which of the following neurochemical changes is responsible for lowering seizure threshold in bupropion therapy for depression?
A) High-affinity antagonism at central GABA-a receptor chloride channels
B) Accumulation of synaptic dopamine and norepinephrine leading to excessive firing of excitatory networks
C) Potent uncoupling of neuronal Na/K-ATPase pumps in the hippocampus
D) Blockade of presynaptic alpha2-adrenergic autoreceptors triggering a catecholamine storm
Accumulation of synaptic dopamine and norepinephrine leading to excessive firing of excitatory networks
Which of the following monoclonal antibodies inhibit RANKL?
A) Romosozumab
B) Denosumab
C) Burosumab
D) Adalimumab
Denosumab
A patient with acute DVT receives heparin. After 7 days, platelet count drops to 45,000/microlitre. Which anticoagulant is most appropriate now?
a) low molecular weight heparin
b) argatroban
c) fondaparinux
d) protamine sulfate
argatroban
Which of the following parameters do not determine plasma steady state concentrations of a drug administered orally?
a) bioavailability
b) dose rate
c) clearance
d) half-life
half-life