Neuro & Psych
Pulmonary
Pediatrics
Endocrine
Heme/Renal
100

Clinical Vignette:


35F with new-onset headaches, nausea, and vision changes. Papilledema on exam.

Board Question: What is the most likely diagnosis? Treatment?

A. Pseudotumor cerebri

B. Meningitis

C. Idiopathic intracranial hypertension

D. Cluster headache

Correct Answer: 

C - Idiopathic intracranial hypertension

Treatment:


100

Clinical Vignette:
60M with chronic cough, clubbing, and recurrent infections. CXR shows bronchiectasis.

Question: What is the most likely diagnosis? Treatment?

A. Asthma

B. Bronchiectasis

C. Tuberculosis

D. COPD

Correct Answer: 

B - Bronchiectasis

Treatment: 

100

Clinical Vignette:
4F with barking cough, inspiratory stridor. Steeple sign on X-ray.

Question: What is the most likely diagnosis? Treatment?

A. Epiglottitis

B. Bronchiolitis

C. Croup

D. Asthma

Correct Answer: 

C - Croup (laryngotracheobronchitis)

Treatment: 

100

Clinical Vignette:
50F with fatigue, cold intolerance, dry skin. TSH elevated, T4 low.

Question: What is the most likely diagnosis? Treatment?

A. Subacute thyroiditis

B. Graves disease

C. Hashimoto’s

D. Central hypothyroidism

Correct Answer: 

C - Primary hypothyroidism (Hashimoto’s)

Treatment: 

100

Clinical Vignette:
68M with fatigue, low MCV, positive FOBT.

Question: What is the most likely diagnosis? Treatment?

A. Iron deficiency anemia

B. Anemia of chronic disease

C. Thalassemia

D. Lead poisoning

Correct Answer: 

A - Iron deficiency anemia

Treatment: 

200

Clinical Vignette:
22M with worsening depression, insomnia, and weight loss. No suicidal ideation. 

Question: What is the most likely diagnosis? Treatment?

A. Bipolar disorder

B. Major depressive disorder

C. Adjustment disorder

D. Schizophrenia

Correct Answer: 

B - Major Depressive Disorder

Treatment:

200

Clinical Vignette:
55F with 20 pack-year smoking history, dyspnea, wheezing, productive cough.

Question: What is the most likely diagnosis? Treatment?

A. Chronic bronchitis

B. Asthma

C. Lung abscess

D. Sarcoidosis

Correct Answer: 

A - Chronic bronchitis (COPD)

Treatment: 

200

Clinical Vignette:
2M with fever, irritability, bulging fontanelle. LP shows high WBC and low glucose.

Question: What is the most likely diagnosis? Treatment?

A. Viral meningitis

B. Bacterial meningitis

C. Sepsis

D. Hydrocephalus

Correct Answer: 

B - Bacterial meningitis

Treatment: 

200

Clinical Vignette:
30F with weight gain, purple striae, moon facies. High cortisol levels.

Question: What is the most likely diagnosis? Treatment?

A. Addison’s disease

B. Cushing syndrome

C. Pheochromocytoma

D. Hyperthyroidism

Correct Answer: 

B - Cushing syndrome

Treatment: 

200

Clinical Vignette:
17F with hematuria after sore throat, RBC casts in urine.

Question: What is the most likely diagnosis? Treatment?

A. IgA nephropathy

B. Post-strep GN

C. HSP

D. Minimal change

Correct Answer: 

A - IgA nephropathy

Treatment: 

300

Clinical Vignette:
70M with memory issues, getting lost, repeating questions, poor recall.

Question: What is the most likely diagnosis? Treatment?

A. Frontotemporal dementia

B. Lewy body dementia

C. Alzheimer’s

D. Vascular dementia

Correct Answer: 

C - Alzheimer's disease 

Treatment: 

300

Clinical Vignette:
28M with hemoptysis, hematuria, and linear IgG on kidney biopsy.

Question: What is the most likely diagnosis? Treatment?

A. Goodpasture

B. GPA

C. PE

D. Post-strep GN

Correct Answer: 

A - Goodpasture syndrome

Treatment: 

300

Clinical Vignette:
6F with itchy rash, vesicles on erythematous base in different stages.

Question: What is the most likely diagnosis? Treatment?

A. Measles

B. Rubella

C. Varicella

D. Scarlet fever

Correct Answer: 

C - Varicella (chickenpox)

Treatment: 

300

Clinical Vignette:
25M with episodes of sweating, palpitations, and tremor relieved by eating.

Question: What is the most likely diagnosis? Treatment?

A. Insulinoma

B. Glucagonoma

C. Somatostatinoma

D. Zollinger-Ellison syndrome

Correct Answer: 

A - Insulinoma 

Treatment: 

300

Clinical Vignette:
45M with bone pain, anemia, renal failure, and elevated protein gap.

Question: What is the most likely diagnosis? Treatment?

A. Multiple myeloma

B. Waldenstrom's

C. AML

D. Renal cell carcinoma

Correct Answer: 

A - Multiple myeloma

Treatment: 

400

Clinical Vignette:
45F with rest tremor, bradykinesia, and stooped posture.

Question: What is the most likely diagnosis? Treatment?

A. Parkinson’s

B. Huntington’s

C. Wilson’s

D. Essential tremor

Correct Answer: 

A - Parkinson’s disease

Treatment: 

400

Clinical Vignette:
35F with non-productive cough, bilateral hilar lymphadenopathy.

Question: What is the most likely diagnosis? Treatment?

A. TB

B. Sarcoidosis

C. Pneumonia

D. Bronchitis

Correct Answer: 

B - Sarcoidosis

Treatment: 

400

Clinical Vignette:
3M with lethargy, vomiting, hepatomegaly after aspirin use.

Question: What is the most likely diagnosis? Treatment?

A. Viral hepatitis

B. Reye syndrome

C. Liver abscess

D. Biliary atresia

Correct Answer: 

B - Reyes syndrome 

Treatment: 

400

65M with hypercalcemia, low PTH, metastatic breast cancer history.

Question: What is the most likely diagnosis? Treatment?

A. Primary hyperparathyroidism

B. Hypercalcemia of malignancy

C. Sarcoidosis

D. Vitamin D toxicity

Correct Answer: 

B - Hypercalcemia of malignancy

Treatment: 

400

Clinical Vignette:
30F with SLE history, proteinuria, HTN, and edema.

Question: What is the most likely diagnosis? Treatment?

A. FSGS

B. Diabetic nephropathy

C. Lupus nephritis

D. Minimal change

Correct Answer: 

C - Lupus nephritis 

Treatment: 

500

Clinical Vignette:
30M with multiple personality changes, aggressive outbursts, and chorea.

Question: What is the most likely diagnosis? Treatment?

A. Multiple sclerosis

B. Huntington’s

C. ALS

D. Encephalitis

Correct Answer: 

B - Huntington’s disease

Treatment: 

500

Clinical Vignette:
24M with sudden onset dyspnea during basketball, hyperresonance on exam.

Question: What is the most likely diagnosis? Treatment?

A. Hemothorax

B. Asthma

C. Spontaneous pneumothorax

D. PE

Correct Answer: 

C - Spontaneous pneumothorax

Treatment: 

500

Clinical Vignette:
7M with petechiae after viral illness, low platelets on labs.

Question: What is the most likely diagnosis? Treatment?

A. Leukemia

B. ITP

C. DIC

D. HSP

Correct Answer: 

B -  Immune thrombocytopenic purpura (ITP)

Treatment: 

500

Clinical Vignette:
40M with enlarged jaw, hands, feet. Elevated IGF-1 and GH levels.

Question: What is the most likely diagnosis? Treatment?

A. Acromegaly

B. Gigantism

C. Marfan syndrome

D. Cushing’s

Correct Answer: 

A - Acromegaly

Treatment: 

500

Clinical Vignette:
55F with schistocytes, thrombocytopenia, renal dysfunction, neuro signs.

Question: What is the most likely diagnosis? Treatment?

A. TTP

B. ITP

C. DIC

D. HIT

Correct Answer: 

A - Thrombotic thrombocytopenic purpura (TTP)

Treatment: 

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