Endocrine Drugs
Blocks TPO, can be used during first trimester
PTU
Drug given to delay puberty and how is it administered?
Leuprolide; continuously
headache, flushing, dyspepsia, cyanopia, hypotension while taking nitrates
PDE5 inhibitors
Agonist of u-opoid receptor, slows gut motility
Loperamide
What is the treatment for carcinoid tumors?
octreotide
What drug is used to treat exophthalmos in graves disease?
Steroids
Clomiphene
Tamsulosin mechansim
alpha1 antagonist selective for alpha 1A/D (prostate)
What is first line for treating c diff?
Vancomycin oral (NOT metonidazole anymore)
What 2 conditions do bromocriptine treat?
Prolactinoma and acromegaly
Name a hematologic side effect of methimazole
agranulocytosis and aplastic anemia
List 3 contraindications for combined estrogen and progesterone contraceptives
1. Smoker >35 y/o
2. CVD high risk
3. Migraines w/ aura
4. Breast cancer
5. Liver disease
What enzyme does ketoconazole inhibit?
17 alpha hydroxylase/17,20 desmolase
What drug is used to treat a mild case of UC?
Severe case of UC? (6 or more fatty/bloody stools per day)
Sulfasalazine = mild
Infliximab = severe
Treats endometriosis and hereditary angioedema, synthetic androgen that acts as partial agonist at androgen receptors
Danazol
What drug treats SIADH and causes neurogenic DI
Demeclocycline
What is the difference in mechanism of tamoxifen vs raloxifene (agonism vs antagonism)
Tamoxifen: antagonist at breast, agonist at bone and uterus
Raloxifene: antagonist at breast and uterus, agonist at bone
Nonsteroidal competitive inhibitor at androgen receptors; treats prostate carcinoma
flutamide
Inhibts gastric and pancreatic lipase, decreases breakdown and absorption of dietary fats --> weight loss drug!
Orlistat
List 3 drugs to treat thyroid storm
Propanolol (beta blockers)
PTU
Corticosteroids
Potassium iodide
Give the mechanism of Cinacalcet
Sensitizes Ca2+ receptor (CaSR) in parathyroid gland to circulating Ca2+ --> decreasing PTH
Mechanism of mifepristone vs mechanism of misoprostol
mifepristone: competitive inhibitor at progesterone receptors
Misoprostol: PGE1 agonist
Promotes burn recovery (stimulates anabolism)
Name a drug that inhibits H1 receptors
Diphenhydramine, etc
What GI SPECIFIC drug increases risk of c diff?