I/MOA
donepezil indication and MOA?
alzeimers (mild-severe)
CNS selective, reversible and noncompetitive inhibitor of AChE
sinemet DF?
PO
donepezil ADR and DI?
N/V/D, application site rxn, insomnia, prolonged QTC, bradycardia
3A4, 2D6, anticholinergic, NSAID
Aricept CI?
piperidine derivatives
aricept PC and M?
do not crush or chew, take at bedtime, avoid heat sources with patch
mental status, wt, GI intolerance, GI bleed
pramipexole indication and MOA?
parkinsons, restless leg syndrome
non ergot DA agonist stimulating DA activity
requip DF and PK?
PO
renal
pramipexole ADR and DI?
C/N/V, dizzy, drowsy, HA, insomnia, augmentation, impulse control disorders, ortho hypo, hallucinations, dyskinesia
OCT2, anti-psych agents
Which neuro med is available in a patch?
mirapex PC and M?
do not chew or crush, impulse control issues, titrate slowly, avoid alc
vital signs, wt changes, BP, behavior
memantidine indication and MOA
alzeimers
moderate affinity noncompetitive NMDA receptor antagonist
Namenda DF and PK?
PO
renal
confusion, HA, dizzy, agitation, delusion, hallucinations, CNS effects, SJS, DVT, hepatitis, liver failure
OCT2, Na bicarb, other NMDA antags
Which neuro med has DI with 3A4 and 2D6?
Aricept (donepezil)
Namenda PC and M?
do not crush or chew, avoid abrupt d/c titrate slowly, do not mix oral soln with any other liquids
cognitive fx
ropinirole indication and MOA?
parkinsons, restless leg syndrome
stimulates postsynaptic DA receptors in the brain
mirapex DF and PK?
PO
renal
ropinirole ADR and DI?
HTN/hypoTN, N/V, infection, dizzy, drowsy, sleep attacks, WD syndrome, poor impulse control, ortho hypo, back pain, augmentation
1A2 (smoking), antipsych meds
Which meuro med has DI with 1A2?
requip PC and M?
do not crush or chew, cation impulsive behavior, smoking interactions
BP, daytime alertness, fall risk, behavior
carbidopa/levadopa indication and MOA?
parkinsons
crosses BBB and converted to DA inhibit peripheral breakdown plasma breakdown of levadopa making more available
aricept DF?
carbidopa/levodopa ADR and DI?
ortho hypo, C/N, depression, dizzy, HA, increased SCr, BUN, WD syndrome
MAOI within 14d
Which neuro med do you need to separate from iron supplements?
Sinemet (carbidope/levadopa)
sinemet PC and M?
do not crush or chew, avoid high protein intake, separate from iron supplements
hepatic fx, CBC, SCr, BUN, BP, mental status