AJCC 8th Ed Staging
This is the only way a p16+ patient can be overall stage IV
Distant metastasis
This is a surrogate marker for HPV tumor status
What is p16?
What are radiation and transoral surgery?
This is the most common long-term side effect of head and neck radiation therapy
These are the HPV types that cause genital warts
What are HPV6 and 11?
In p16+ disease, bilateral nodes ≤6 cm fall under this N category
This HPV oncoprotein degrades p53
What is E6?
Ligation of these two vessels reduced the risk of major bleeding after transoral robotic surgery
What are the lingual and facial arteries?
The lingual surface of the epiglottis is part of this major head and neck cancer site
What is the larynx?
This nodal categories (or greater) in HPV-negative OPC result in Stage IVA+
What is N2?
This is the lining epithelium of the oropharynx
What is non-keratinized stratified squamous epithelium?
This is the number of weeks after surgery when radiation therapy should be initiated to avoid a survival decrement.
What is 6?
What is the superior pharyngeal constrictor?
This is the most sensitive test for recurrence of HPV(+) OPC
What is circulating tumor HPV DNA (NavDx)?
This is the most important prognostic risk factor that does not change AJCC stage
What is smoking pack-years (>10)?
These are the subsites of the oropharynx
What are palatine tonsillar complex, base of tongue, soft palate, and pharyngeal wall?
This is the most significant surgically-based treatment deintensification trial
What is ECOG 3311?
This anatomic variant is a contraindication to transoral robotic surgery
What is a retropharyngeal internal carotid artery?
This is the number of HPV types covered by the Gardasil vaccine
This % of nuclear and cytoplastic p16 staining defines HPV-positive staging
This is the gold standard test for transcriptionally active HPV
What is E6/E7 mRNA in situ hybridization?
This is the most common non-lung site of distant metastasis in HPV(+)OPC
Bone
This is the mechanism of action of the most common chemotherapy used in head and neck cancer
What is binding to DNA, forming cross-links to cause DNA damage?
This is the clinical stage of a 5 cm p16+ tumor with extension to the lingual surface of the epiglottis, depth of invasion 3 cm
What is stage T3?