I've got you under my skin
Did I do it to myself?
You are contagious
It's all in your head
I am my worst enemy
Feeling Rejected
Hodge Podge
100
The pathognomonic lesion of acne
comedone
100
This mechanism, proposed to induce autoimmunity, is a result of viral or bacterial protein epitopes similar to the host's self-components.
What is 'molecular mimicry'?
100
Extensive vesicular and pruritic rash and the lesions are in various stages of healing
What is chickenpox?
100
Wet or dry, drusen are usually there
Macular degeneration
100
Antinuclear (ANA) and Anti-Smith (Sm)
What are autoantibodies for SLE (Lupus)?
100
It is when you give an organ to someone and they don't accept it!
What is transplant rejection?
100
A patient with chronic Rheumatoid arthritis can have this type of extracellular deposits of fibrillar proteins (be specific)
What is AA (amyloid-associated) amyloidosis?
200
Benign lesions with crater-like morphology
Keratoacanthoma
200
This autoimmune disease affects 0.2% of the population and is caused by an autoimmune attack on the pancreas.
What is Insulin-dependent diabetes mellitus (IDDM), or What is Type 1 diabetes mellitus?
200
This lesion is composed of the following cells
What is a caseating granuloma?
200
This cancer, characterized by keratin pearls, makes up 95% of head and neck cancers.
Squamous cell carcinoma
200
This is the most sensitive autoantibody for SLE
What is ANA (anti-nuclear antibody)?
200
A tissue graft from a donor of the same species as the recipient but not genetically identical
What is an allograft?
200
A 55-year-old Japanese woman has amyloidosis associated with rheumatoid arthritis. She presents with nephrotic syndrome and renal biopsy specimens are obtained. This renal section is stained with the following stain.
What is congo red stain?
300
Sometimes a signal of occult malignancy when many suddenly appear, but more often occur as "barnacles on the ship of life" as greasy, dark plaques.
seborrheic keratosis
300
This disease presents as an overlap of SLE, Systemic sclerosis, and Polymyositis
What is Mixed connective tissue disease?
300
Maine will be testing newborn for this virus
What is Cytomegalovirus (CMV)?
300
In some parts of Africa, where EBV is endemic, this is the most frequent childhood cancer.
nasopharyngeal carcinoma
300
Check for this autoantibody for drug-induced lupus
What is anti-histone antibody?
300
A tissue graft or organ transplant from a donor of a different species from the recipient.
What is Xenograft?
300
It is also called Vitamin C
What is ascorbic acid?
400
This skin cancer precursor is famous for its cutaneous horns and association with sun exposure.
Actinic keratosis
400
The patient with the following signs and symptoms has this disease. 
What is Lupus (SLE)?
400
Painful,erythematous and burning rash in a dermatomal pattern
What are shingles (herpes zoster)?
400
Because of this, yellow soft cotton wool spots are formed in the retina 
What is ischemia?
400
This autoantibody is most specific for lupus nephritis
What is dsDNA?
400
These are responsible for hyperacute graft rejection
What is the role of pre-formed antibodies?
400
This important component of the connective tissue is defective in this sailor
What is collagen?
500
Characterized by palisading cells surrounding basophilic nests, it's also the most common eyelid malignancy.
Basal cell carcinoma
500
A 24-year-old female presents to her doctor with increased joint pain over the last six months. On further questioning, she admits to noticing ankle swelling at the end of each day and having a rash that appears across her cheeks and nose after she has been working outside. A complete blood count reveals a platelet count of 90,000/mm3 (150,000 to 400,000/mm3) but otherwise is within normal limits. These are the most specific antibodies for her condition.
What are Anti-dsDNA or anti-Smith antibodies?
500
It is a pathology test showing multinucleated giant cell and intranuclear inclusions in HSV and VZV infection
What is the Tzanck smear?
500
Seen especially in immunocompromised patients, it is a fluffy, hyperkeratotic thickening on the lateral border of the tongue.
hairy leukoplakia
500
Anti-U1-RNP (ribonucleoprotein)
What are autoantibodies for Mixed connective tissue disease?
500
Manifests as interstitial fibrosis and gradual narrowing of graft blood vessels (graft arteriosclerosis)
What is chronic graft rejection?
500
This pathological change is visible on a liver biopsy from this child
What is microvesicular steatosis?
600
This pattern of destruction is visible along the dermoepidermal junction in lichen planus.
Zigzag (or sawtooth)
600
The occurrence of this type of lymphoma is the most serious complication of Sjogren's syndrome (SS).
What is Non-Hodgkin's lymphoma (NHL)?
600
Congenital infection with this virus causes Microcephaly and Periventricular Calcifications
What is CMV or Cytomegalovirus?
600
Surf's up! The fancy name for this fleshy, vascular mass that grows over the cornea.
pterygium
600
Anti-DNA topoisomerase antibodies
What autoantibody is specific for Systemic Sclerosis?
600
It occurs a few minutes after the transplant when the antigens are completely unmatched
What is hyperacute graft rejection?
600
The deficiency of this vitamin caused keratinized patches over her conjunctiva (figure)
What is vitamin A deficiency?
700
These nonacantholytic blisters occur when antibodies target hemidesmosomes
bullous pemphigoid
700
What is the mechanism of lupus flares when exposed to sunlight?
700
The biopsy specimen shows multiple enlarged cells with basophilic intranuclear inclusions and a surrounding halo
What are CMV inclusion bodies?
What are CMV-infected cells?
700
This substance is commonly produced by sympathetic paragangliomas, but rarely by the parasympathetic types.
Catecholamines
700
This autoantibody is associated with a higher likelihood of CREST syndrome
What is Anti centromere antibody?
700
It occurs when the pre-formed antibodies bind to antigens on the graft endothelium and activate the complement and clotting systems leading to endothelial injury, thrombus formation, and ischemic necrosis of the graft
What is hyperacute graft rejection?
700
What is scurvy?
800
Seeding of blood by malignant T cells can lead to this diffuse erythema and scaling of the entire body surface.
Sezary syndrome
800
Order this specific antibody to diagnose this patient
What is anti-DNA topoisomerase I (anti-Scl 70) antibody?
800
It is this lesion shown here in a pulmonary resection specimen with a rounded calcified nodule 
What is a Ghon focus of Tuberculosis?
What is a caseating granuloma?
800
This developmental cyst usually presents around the crown of an unerupted tooth in the mandible.
Dentigerous cyst
800
Antibodies against these two antigens can be detected in as many as 90% of patients with Sjogren syndrome.
What are SS-A (Ro) and SS-B (La)?
800
A 37-year-old man presents with abdominal pain, diarrhea, vomiting, and jaundice. His medical history was significant for acute lymphoblastic leukemia diagnosed 1 year ago. Following ablative chemotherapy, he received a bone marrow allograft from a related donor.
On physical examination, a maculopapular rash is present over his neck, shoulders, palms, and soles. Laboratory studies show elevated AST and ALT. He most likely has this disease.
What is Graft vs Host Disease?
800
These are the radiodense lines in the metaphysis and epiphysis of the children in the following scenario
What are the lead lines?
900
Whereas HLA-B locus alleles are strongly associated with psoriatic arthritis, this other class of HLA locus alleles are more strongly associated with cutaneous psoriasis.
HLA-C
900
In this syndrome, the patient presents with the following features.
What is CREST syndrome?
- C is for Calcium deposits in the body tissues
- R stands for Raynaud’s Phenomenon
- E is for Esophageal reflux, commonly referred to as heartburn
- S is for Sclerodactyly or thick skin on the fingers
- T is for Telangiectasias which are enlarged blood vessels that appear as red spots on the face and other areas
900
This is what the liver biopsy shows.
What is microvesicular steatosis?
900
Cervical lymphoepithelial cysts along the sternocleidomastoid muscle most commonly arise from this branchial arch.
What is the second branchial arch?
900
This is what happened to her
What is drug-induced SLE? (Phenytoin)
900
It is one of the most common opportunistic viral infections that affect the outcome of solid organ transplantation.
What is cytomegalovirus?
900
The deficiency of a particular vitamin causes these two conditions called ---- and ------
What are Xerophthalmia and Bitot spots? (Vitamin A deficiency)
1000
The disease you associate with these granules, and hepatosplenomegaly, signs of bone marrow invasion, and a condition mimicking seborrheic dermatitis.
Langerhans cell histiocytosis (Letterer-Siwe Disease)
1000
What is Mixed connective tissue disease?
1000
Male age 52
Tissue: Lung
This HIV-positive patient developed progressive weight loss, fever and cough. He was found to have multiple small opacities in the lungs on X-ray. He was started on the appropriate treatment but his general condition deteriorated and he died 2 weeks after admission. The section is taken from one of the lungs.
https://www.virtualpathology.leeds.ac.uk/ug/week.php?number=5&case_id=243
What is miliary Tuberculosis?
1000
Associated with cigarette smoking, this parotid gland lesion contains oncocytic cells on a lymphoid stroma.
Warthin tumor (Papillary cystadenoma lymphomatosum)
1000
Mothers with these autoantibodies should be counseled regarding the risk of NLE (neonatal lupus erythematosus)
What are SSA/Ro and/or SSA/La antobodies?
1000
In this type of transplant rejection, we see the following changes
Tubulointerstitial fibrosis
What is chronic rejection?
1000
This type of amyloidosis is seen in this particular disease
What is Multiple Myeloma?