yo... GABA GABA!
DOPE-amine
Ad-RUN-aline
Never Enough Serotonin!
High as a Kite! (thanks cannabinoids)
100

True or False:

There are 3 types of GABA. Name all!

True. The 3 types are: GABAA, GABAB, GABAC 

GABAA is the focus.

100

What family of molecules is dopamine apart of?

Monoamine Family, and is a catecholamine

100

What molecule is involved with the production of Adrenaline

Dopamine
100

What is serotonin publicly known for?

Happiness and Better Moods

100
What receptors mediate cannabinoids
Cannabinoid (CB) receptors
200

How many subunits make up the GABAA receptor?

*Picture of Receptor*

5 

2 are alpha units, 2 are beta units, and 1 is gamma

200

What does DBS stand for?

Deep Brain Stimulation - a method in which electrodes are implanted on the subthalamic nucleus or globus pallidus to modulate its activity

200
What is the main area where adrenergic neurons are found? What are some innervations involved?

Locus coeruleus

Innervations: Hippocampus, prefrontal cortex, and basolateral amygdala

200
What is the transporter of serotonin called?

5-HT Transporters (SERT)

200

What is the runner's high

After exercising, one may have positive psychological states

300

What GABAA receptors are linked to impaired memory?

alpha-5GABAAR and delta-5GABAAR

300
What are the different Dopamine Pathways?

Mesocortical, Mesolimbic, Tuberoinfundibular, and Nigrostriatal

300
What brain structures are involved in a person's arousal/wakefulness

Thalamus, Hypothalamus, Basal Forebrain, and Spinal Cord

300

DAILY DOUBLE!! What can be a reason for anxiety?

During stress, acute increases in serotonin transmission to the limbic system may cause anxiety, can lead to "jitteriness syndrom"

300
What are the targets of THC and CDB?

THC is a partical agonist of CB1Rs

CBD affects many receptors

400

What is Long-Term Potentiation?

When stimulation of synaptic connections is at a high-frequency, thus leads to increased strength.

400

How do you increase dopamine in the system?

Because dopamine itself can't cross the blood-brain barrier, L-DOPA, a precursor for dopamine can be administered

400

What is the affect of the loss of orexin-expressing neurons? What is the condition called?

Narcolepsy, excessive daytime sleepiness

400

What is the Monoamine Hypothesis?

The decrease in monoamine neurotransmitters (e.g. norepinephrine and serotonin) may lead to bad moods and/depressive-like behaviour

400

What are the potential benefits of Cannabinoids?

1. Epilepsy 

2. Pain

3. Mood

500

*Picture of Graph*

What does this graph indicate about delta-GABAAR and depression-like behaviour in post-partum individuals?

Deletion of the delta-GABAAR leads to depressed-like behaviour. This can be supported by the depletion of immobility for longer periods of time (supported by bar graph)

500

FINAL JEOPARDY!!! What are the risk factors for addiction?

- stability of home environment

- early use + peer pressure

- education

- employment

- genetics

- gender

- mental health status

500

What is the common name of beta-adrenergic blocker? What are the effects?

Propanolol, it reduces PTSDs symptoms in memory reactivation

500
What is supporting evidence for the monoamine hypothesis?

1. reserpine depletes monoamines which produce depression-like behaviour

2. low levels of monoamine metabolites are found in depressed individuals

3. tryptophan depletion can trigger depression

4. most drugs that treat depression are monoamines

500
What is the side effect of cannabis use?

Cannabis Use Disorder, affects attention, psychomotor function, executive function, paranoia, memory, and attention

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