Antidepressants
Antipsychotics
Substance Use Disorders
Adverse Effects of Psychotropics
Anything Under the Sun
100
What 2 antidepressants can cause withdrawal symptoms if a single dose is missed?
Paroxetine, venlafaxine
100
Aripiprazole is available as 2 formulations. What are they?
oral tablet & long-acting IM injection
100
Name 3 prescription drugs that have street value (excluding narcotics & benzos)
• Amphetamines/stimulants: Dexedrine (dextroamphetamine), Adderall (mixed salts), Ritalin/Concerta/Biphentin (methylphenidate), Vyvanse (lisdexamfetamine) • Dextromethorphan • Anticholinergics (trihexyphenidyl, benztropine, baclofen, quetiapine, dimenhydrinate) • Bupropion • Gabapentin • Zopiclone, zolpidem
100
Benztropine can be used for which of the following type(s) of EPS: a) Acute dystonia b) Tardive dyskinesia c) Akathisia
acute dystonia
100
When should a lithium level be drawn? a) Peak b) 12 hour trough c) 24 hour trough
12 hour trough
200
What dose does venlafaxine XR start to exhibit noradrenergic properties?
150mg
200
What is the difference between Clopixol, Clopixol Acuphase & Clopixol Depot?
Formulation and duration of action of IM injection
200
Withdrawal from which 2 classes can be potentially life threatening? a) alcohol b) benzodiazepines c) opioids d) stimulants
alcohol & benzodiazepines
200
State 3 differences in presentation between neuroleptic malignant syndrome and serotonin syndrome
medication history (pro-serotonergic drug vs dopamine antagonist), time to onset (< 12 hrs vs 1-3 days), pupils (mydriasis vs normal), bowel sounds (hyperactive vs normal/decreased), neuromuscular tone (increased in lower extremities vs “lead-pipe” rigidity in all muscle groups), reflexes (hyperreflexia vs bradyreflexia), mental status changes (agitation vs stupor)
200
List 3 non-psychiatry drugs that can contribute to serotonin syndrome
analgesics (meperidine, fentanyl, tramadol), antiemetic agents (ondansetron, metoclopramide), antimigraine drugs (sumatripan), linezolid, dextromethorphan, MDMA, St. John’s wort, ginseng
300
What is the most rationale antidepressant combination? a) TCA + MAOI b) SSRI + TCA c) SSRI + bupropion d) SSRI/SNRI + mirtazapine
SSRI + bupropion
300
What depot antipsychotic do we initiate with a loading dose?
Paliperidone palmitate (Invega Sustenna)
300
Name 1 prescription medication and 1 illicit substance that can cause drug-induce psychosis
Prescription medication: amphetamines, corticosteroids, dopamine (levodopa), dopamine agonists (ropinirole, pramipexole) Illicit substances: cannabis, cocaine, LSD
300
There have been clozapine-related deaths in Canada due to which of the following side effects (pick 2)? a) agranulocytosis b) constipation c) myocarditis
constipation & myocarditis
300
Name 1 difference between zopiclone and zolpidem
half-life
400
Which TCA is gold standard for treatment of OCD?
Clomipramine
400
What 2 antipsychotics must be taken with meals to ensure complete absorption?
ziprasidone & lurasidone
400
How many days of missed Suboxone doses can lapse before the dose has to be adjusted or re-titrated?
5 days
400
Name 1 antidepressant that has NOT been associated with QT prolongation at therapeutic doses
duloxetine, bupropion, paroxetine
400
Aripiprazole can be used as monotherapy for treatment of depression. True or false?
False
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