biology
A gene test to identify those with increased risk of allopurinol hypersensitivity reaction
HLA B*58:01
- Allopurinol hypersensitivity syndrome is a rare side effect from allopurinol
- Patients with HLA-B*58:01 are at increased risk
- High prevalence of gene in ethnic groups: Korean, Han Chinese, Thai, African
-Conditional recommendation to screen high risk populations prior to initiation of allopurinol