Powders & Blending
A powder is best defined as what physical type of substance?
Tablets must have predictable ... ?
Dissolution
Name the 3 types of Aerosol delivery devices
MDIs, DPIs, Nebulizers
PK is Concentration vs. __
Time
What route avoids first-pass metabolism?
Inhalation
What blending method uses a pill tile?
Spatulation
Which capsule type has a plasticizer:gelatin ratio of 0.8:1?
Soft gelatin capsules
What particle size reaches the alveolar region?
< 2 um
PD is Concentration vs. __
Effect
Name one major parenteral route
Intravenous (IV)
Intramuscular (IM)
Subcutaneous (SC)
What is the name of the process where equal volumes of drug and diluent are repeatedly mixed?
Geometric dilution
Name an advantage of capsules over tablets.
Possible answers:
Better masking of taste/aroma
Easier to formulate, manufacture, vary dose, combine APIs, swallow
Suitable for blinded clinical trials
Useful for extemporaneous compounding by Rph
What percentage of aerosol propellants are liquefied gases?
90%
In the Henderson-Hasselbalch equation, pH = pKa + log ( __ / __ )
[base/acid]
[A-]/[HA]
What barrier prevents many drugs from entering the CNS?
Blood-brain barrier
Name a type of pharmaceutical powder that is NOT pressurized.
Correct answers:
Bulk Powders
Dusting Powders
Douche Powders
Divided Powders
What excipient helps a tablet break apart in the GI tract?
Disintegrant
Name one QC test for aerosols
Spray pattern
Leak test
Vapor pressure
Flame extension
At pH < pKa, which species predominates for a weak acid?
HA (unionized acid)
Which system distributes nanoparticles throughout the organism?
Lymphatic system
List 3 blending methods mentioned.
Spatulation
Trituration
Sifting
Tumbling
A size 1 capsule has a volume of approximately how many mL?
0.5 mL
Particle Classifying Cascade Impactor
Flumequine (an acid) has a pKa of what value?
6.27
Name 3 reasons dosage forms are needed (from the big list)
1- Accurate dose
2- Protection of drug
3- Protection from gastric juice
4- Masking taste and odor
5- Placement of drugs within body tissues
6- Sustained release medication
7- Controlled release medication
8- Optimal drug action
9- Insertion of drugs into body cavities
10- Make insoluble drugs soluble