HALF-LIVES,
FULLER LIVES
FULLER LIVES
Fluoxetine (Prozac)
This 2011 study showed promise in 118 patients after 20mg of fluoxetine post-stroke
FLAME: Fluoxetine for motor recovery after acute ischaemic stroke (FLAME)
Consensus on multiple sources agree that about his percent of patients become depressed after a stroke
40%
This SSRI has the shortest half-life
Fluvoxamine (Luvox)
This drug was used in trials for stroke because of its long half-life
Fluoxetine (prozac)
DAILY DOUBLE:
This class of drugs has been shown to slow recovery after stroke
Benzodiazepines
GI distress is caused by an increase in this gut function by serotonergic activity
Motility
This stroke scale is typically used in ERs and wards across the United States
NIH stroke scale (NIHSS)
Severe stroke is classified as AT LEAST this many points on the NIHSS
20
DAILY DOUBLE:
The bleeding caused by SSRIs is caused by affecting this clotting activity
Platelet
This stroke scale goes by the acronym HAM-D.
Hamilton Depression Rating Scale
The FLAME trial was conducted for this many months, vs 6 months for the FOCUS trial
3
You may see a worsening of this mental illness with administration of an SSRI
Mania in Bipolar depression
This study, published in 2019 out of the UK, showed an increased risk of bone fracture and no improvement in functional outcomes after 6 months on fluoxetine vs placebo.
Fluoxetine Or Control Under Supervision (FOCUS)
Serotonin on these two classes of cells are postulated to contribute to risk of bone fracture with SSRIs.
osteoclasts and osteoblasts