TH
What is the targeted core temperature?
32°C – 34 °C (89.6°F – 93.2°F)
Cardiac arrest and return of spontaneous circulation (ROSC) results in ______ - ________ injury.
Ischemia-perfusion
Name the three phases of TH.
1) Induction
2) Maintenance
3) Rewarming
What is the purpose of TH?
Decrease mortality rate and increase neurological outcome
How does TH maintain neuronal integrity?
Reduces excitatory amino acids (glutamate, glycine)
True or False:
Rewarming phase begins 24 hours after patient reaches the targeted core temperature.
False:
Rewarming phase begins 24 hours after initiating cooling measures.
On average, cerebral oxygen demand and consumption is reduced by ____.
5% per 1°C
List 3 mechanisms of action involved in TH.
- Maintains neuronal integrity(reduces excitatory amino acids)
- Prevents apoptosis
- Decreases brain metabolism and oxidative stress (lowers cerebral metabolic rate, oxygen and glucose consumption, lactate levels, free radials)
- Decreases inflammation, cytotoxic edema, vasculature damage
In the rewarming phase, patient is slowly rewarmed at a temperature increase of __________ until patient reaches 36.0 °C or 37.0 °C.
0.3°C - 0.5 °C every hour