Definitions
The structural and functional changes in the body caused by disease or trauma
Pathology
One of the 2 ways tissues heal; is the regrowth of original tissue. There are only a few that can do this, i.e. the epidermis
Regeneration
Degeneration or wasting away
Atrophy
When does inflammation begin (#1) and when does inflammation end (#2)
#1: Begins at the moment of cell injury
#2: Terminates when the injurious agent is removed
Caused by ischemia
Coagulative
Apoptosis
One of 2 ways that tissues heal; is the formation of a connective tissue scar
Repair
Enlargement of an organ or tissue, due to an increase in cell size
Hypertrophy
Caused by TB and other fungal infections
Caseous
Active process of degradation of dead cells. End point of the pathological process that results in lethal, irreversible cell injury. Hallmarks = alteration in the cells nucleus/ mitochondria and rupture of the cell membrane.
Necrosis
Building blocks of tissue (~28 kinds)
Collagen
Increase in the number of cells
1/3 primary outcomes of inflammation: This occurs after substantial tissue trauma and tissues with little capacity for regeneration or after prolonged edema
Healing with Scar
Caused by pyogenic bacteria (i.e. Staphylococcus aureus)
Liquefactive
An inadequate blood supply to an organ or part of the body
Ischemia
Earliest proteins that provide structural support (like scaffolding) that attracts fibroblasts and macrophages to the healing tissue
Fibronectin
Change in the nature of tissue, from one cell type to another (external stimulus) can be reversible, less likely to lead to cancer i.e. smoking tobacco changes the bronchial epithelium
Metaplasia
1/3 primary outcomes of inflammation: Develops if the underlying cause is not addressed and the agent causing the injury persists for a prolonged period. Repeated episodes of inflammation (acute) on the same tissue. Low grade/ persistent immune reaction.
Chronic Fibrosis
Caused by acute pancreatitis, abdominal trauma
Fatty Necrosis
A naturally occurring substance capable of stimulating cell proliferation, wound healing and occasionally cellular differentiation.
Growth Factors
Proteins secreted by fibroblasts that bind to fibronectin and collagen and stabilize tissue as its undergoing repair
Proteoglycans
Transforms a cell into an abnormal version of itself (internal stimulus); more likely to become cancer, irreversible
What are the 2 components of the inflammatory reaction that have to do with blood vessels and WBCs?
Vascular alterations and Leukocyte Accumulations
Caused by trauma in blood vessel walls
Fibrinoid