Bug Coverage
(T/F) Vancomycin covers pseudomonas.
FALSE
What are AE of Vancomycin?
Red man's syndrome
Nephrotoxicity
MOA of PCN
Inhibit cross-linking for peptidoglycan in the cell wall, leading to autolysis and cell death
_______ are the drugs of choice for ESBL infection.
Carbapenems
In SSI lecture, Rachel said her favorite movie is...
John Wick
Draw the flower diagram of PCN G
Coverage (ESPN): Enterococcus faecalis, S. Pneumo, Strep pryogenes, N. meningitidis
Daptomycin may result in rhabdomyalgia so avoid concomitant ________ therapy.
statin
Which of the following are protein synthesis inhibitors?
A. Sulfonamides
B. Cephalosporins
C. Polymyxins
D. Lincosamides
E. Nitroimidazoles
D. Lincosamides
Fidaxomicin is useful in ____________ infections ONLY. Cannot be used in against other infections.
C. diff
What does hakuna matata mean?
No worries
All gram (+)
List AE of Gentamicin (name at least 2)
Gentamicin is an aminoglycoside so common SE are
-nephrotoxicity
-ototoxicity
-neuromuscular blockade
-fetal harm (avoid in pregnancy)
MOA of vancomycin
Bind to terminal D-ala-D-ala chains on peptidoglycan in cell wall, preventing further elongation of peptidoglycan chain
Patients taking Bacrim have a high risk of anemia so this antibiotic should not be used if patient has ________ deficiency.
G6PD
Inigo Montoya is a character from which 1987 iconic Rob Reiner film?
Draw the flower diagram for TMP/SMX
Gram (+): MSSA, MRSA, S. pneumo, Strep pyrogenes
Gram (-): ALL except ESBL, CRE, L/M/C, Pseudo
No BF coverage
List AE of Biaxin (name at least 2)
Biaxin is the brand name for Clarithromycin which is a macrolide
Common AE of macrolides are:
-QTc prolongation (>500)
-CYP 3A4 inhibitors
-Hepatotoxicity
-GI SE
Medication classes affected by porin channel degradation:
A. Glycopeptides
B. Fluoroquinolones
C. Lincosamides
D. Beta-lactams
E. Oxazolidinones
B. Fluoroquinolones
List AE of Bactrim (list at least 3)
-Hypersensitivity reaction
-Bone marrow suppression and thrombocytopenia
-Hyperkalemia
-Photosensitivity
-INR increase
-Transient increase of SCr
Who was the first character to speak in the first Star Wars movie?
C3PO
Which of the following drugs cover CRE? (Select all that apply)
A. Vabomere
B. Tigecycline
C. Amikacin
D. Lefamulin
E. Xereva
A, B, E
List AE of Zyvox (Know at least 2)
Zyvox is the brand name for Linezolid. Linezolid belongs to the class of oxazolidinones.
Common AE are:
-Myelosuppresion if >2 weeks of therapy
-Peripheral and optic neuropathy (irreversible***)
-Lactic acidosis with longer durations (>28 days)
-Hypoglycemia
-Cannot be used with 2 weeks of concomitant SSRIs and tyramine containing food due to risk of serotonin syndrome
List STATIC antibiotics (name at least 3):
-Macrolides
-Tetracyclines
-Glycyclines
-Oxazolidinones
Bezlotoxumab should be avoided in patients with ____________.
heart failure
What are the names of the infinity stones?
The Space Stone, the Reality Stone, the Power Stone, the Mind Stone, the Time Stone, and the Soul Stone