Shabooey
Whats the main species responsible for cellular and dna damage in aging?
ROS/Free radicals
What color is Prof Joanna Bridger's hair?
purple
Drugs that kill senescent cells are called
Senolytics
Hallmark of ageing
Percentage of UK population over 65 in 2019
19%
Irreversible arrest of cell growth/division
Senescense
Irreversible arrest of cell growth/division from too many divisions.
Replicative senescence
Irreversible arrest of cell growth/division in order to inhibit tumourgenesis.
Oncogene Induced Senescense
Irreversible arrest of cell growth/division due to external noxious stimuli
Stress Induced Premature Senescence (SIPS)
Term for progressive loss of the tips of chromosomes over many divisions
Telomere Attrition
Which core compensatory mechanism is lost/used to maintain baseline in aged organisms?
Adaptive Homeostasis
Senescent cells secreting negative compounds and causing cells near them to become senescent.
Senescent Associated Secretory Phenotype (SASP)
Senescent Astrocytes lead to what disease?
Parkinsons
Senescent adipocytes lead to what condition?
Insulin resistance/T2DM
Vessels stiffen with age due to loss of what protein
Elastin
Nuclear envelope protein deficient in senescent cells
Lamin-B1
Senescent Foam Cells contribute to what complication of atherosclerosis?
Atheroma rupture & Embolism
NF-KB pathway inhibited by what drug?
Metformin
Tumour supressor pathways maintaining cell senescence
p53/p21, p16lnk4a/retinoblastoma protein (pRb)
Increase in what protein in blood vessel walls leads to a decrease in the ability to increase GFR?
Collagen
What is the tissue level cause of a 70yo being more likely to die of heatsroke than a 20yo in the same weather conditions?
Decreased vascular network with age -> decrease thermoregulation.
Increased sympathetic activity in the elderly contributes to what chronic condition?
Hypertension
The mean age of onset for Pernicious Anemia is 60, what explains this?
Decreased absorption of Vitamin B12 with age.
Increased levels of what hormone contribute to osteoporosis in post menopausal women
FSH